수산화인회석과 인산삼칼슘 및 1형 콜라젠 혼합골의 전자빔 조사 효과
Effect of Electron-beam Irradiaton on the Artificial Bone Substitutes Composed of Hydroxyapatite and Tricalcium Phosphate Mixtures with Type I Collagen
박정민, 김성민, 명훈, 이종호, 김민근, 박영욱, 이병철, 이석근,
소속 상세정보
박정민 ( Park Jung-Min ) - 서울대학교 치의학대학원 치학연구소
김성민 ( Kim Soung-Min ) - 서울대학교 치의학대학원 구강악안면외과학교실
명훈 ( Myoung Hoon ) - 서울대학교 치의학대학원 구강악안면외과학교실
이종호 ( Lee Jong-Ho ) - 서울대학교 치의학대학원 구강악안면외과학교실
김민근 ( Kim Min-Geun ) - 강릉원주대학교 치과대학 구강악안면외과학교실
박영욱 ( Park Young-Wook ) - 강릉원주대학교 치과대학 구강악안면외과학교실
이병철 ( Lee Byung-Cheol ) - 한국원자력연구원 양자과학기술개발부
이석근 ( Lee Suk-Keun ) - 강릉원주대학교 치과대학 구강병리학교실
KMID : 0360120130350010038
Abstract
Purpose: The aim of this study is to evaluate the effect and potential of electron beam (E-beam) irradiation treatment to the synthetic bony mixtures composed of hydroxyapatite (HA; Bongros$^{(R)}$ 수식 이미지, Bio@ Co., Korea) and tricalcium phosphate (${\beta}$ 수식 이미지-TCP, Sigma-Aldrich Co., USA), mixed at various ratios and of type I collagen (Rat tail, BD Biosciences Co., Sweden) as an organic matrix.
Methods: We used 1.0~2.0 MeV linear accelerator and 2.0 MeV superconductive linear accelerator (power 100 KW, pressure 115 kPa, temperature $-30{\sim}120^{\circ}C$ 수식 이미지, sensor sensitivity 0.1~1.2 mV/kPa, generating power sensitivity 44.75 mV/kPa, supply voltage $5{\pm}0.25$ 수식 이미지 V) with different irradiation dose, such as 1, 30 and 60 kGy. Structural changes in this synthetic bone material were studied in vitro, by scanning electron microscopy (SEM), elementary analysis and field emission scanning electron microscope (FE-SEM), attenuated total reflection (ATR), and electron spectroscopy for chemical analysis (ESCA).
Results: The large particular size of HA was changed after E-beam irradiation, to which small particle of TCP was engaged with organic collagen components in SEM findings.
Conclusion:The important new in vitro data to be applicable as the substitutes of artificial bone materials in dental and medical fields will be able to be summarized.
키워드
Bone regeneration;Hydroxyapatite;Tricalcium phosphate;Electron beam
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